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Koke is clearly a player that Barcelona want.
Let's be clear.
If Atletico Madrid's Koke is available, then Barcelona want him. Francesc de Haro of Sport noted the possible progression of any €50 million transfer:
Relations between Barcelona and Atletico Madrid are really good at the moment.
[...] These good relations have strengthened during negotiations this summer to incorporate Atleti star Koke at Barca.
[...] Keeping in mind the good relations between the two clubs, Barca are ready to question Atleti and Koke again about the possible signing.
If both the player and the Rojiblancos are receptive, Barça will be ready to make an offer for the services of Koke.
[...] If Koke and Atleti are open to talking, Barcelona will study a formula in which all three parties can come out happy from the operation. One possibility would be to sign the player this summer and loan him back to the Spanish capital. He could then joing Barca next summer.
Whilst any transfer will be difficult, it won't be impossible if all parties are willing to work together.