Brendan Rodgers' young side finished two points behind Manuel Pellegrini's team in 2013/14 and will be looking for a positive result to show that last season wasn't a one-off.
The corresponding fixture last season saw Raheem Sterling wrongly have a goal disallowed, with City taking three points in a 2-1 win.
Vincent Kompany and Alvaro Negredo scored for the home side, with Philippe Coutinho having given Liverpool the lead.
Rodgers must decide whether to give some of his new signings their full debuts in such a high-profile game. Will Alberto Moreno come straight in at left-back? Will Emre Can be added to the midfield?
We take a look at how the Reds will line up on Monday.