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The San Francisco 49ers are coming off three straight years of deep postseason runs that ended without a Super Bowl title. 

Can Jim Harbaugh's team overcome the key injuries? Will his contract issues be a distraction? Who is the voice in the locker room that keeps everyone together?

Watch as Adam Lefkoe goes in depth with Bleacher Report NFL analysts Matt Bowen and Chris Simms in the video above. 

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