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The young striker had two loan spells last season, both in the Championship, neither of which was particularly fruitful.
At Wigan he made two starts and two further substitute appearances without scoring. At Queens Park Rangers he started six times, made four substitute appearances and did not get on the score sheet.
Keane's career has suffered from the 16-month layoff that resulted from his cruciate ligament injury.
By that point he had made his first-team debut at United and was a crucial member of the FA Youth Cup-winning squad of 2011. He has not been able to reach the same level since, understandable given he missed a vital stage in his development as a player.
Predicting where his career goes from here is a challenge. If he does not have a future at United, he needs to find a club prepared to gamble on his potential. The intense, physical nature of the Championship might not be the best bet for him.
Rather, a Premier League club whose manager is interested in youth development and who may have an eye for a bargain seems a good fit.
Everton's Roberto Martinez may be the ideal steward for Keane's career. The club spent uncharacteristically heavily on Romelu Lukaku this summer. Adding to that by taking advantage of a United-trained prospect available at a reasonable price could be a savvy move for all involved.
Keane could provide back-up, an alternative option and a potential strike partner for Lukaku should Martinez ever want to play with two up front. Martinez could certainly help Keane develop.
Perhaps one day the legacy of the cruciate ligament injury could be forgotten, and Keane will be able to fulfill the huge promise he has shown.
Best Destination: Everton