David Zalubowski/Associated Press
Many people predicted these two teams to meet in the Super Bowl last year. There may be just as many people who are predicting it to happen again this season.
But on Sunday, these two teams will merely be playing a preseason game against each other, looking for the best 53 players they have to comprise their final rosters.
Still, these are two of the premier teams in the league at the moment, and places like ESPN and NFL Network will likely show extensive highlights.
Here are some matchups to keep an eye on in this one.
Denver Defensive Line vs. San Francisco Offensive Line
The offensive line of San Francisco has long been touted as one of the best in the NFL. Built on strength and physicality, these guys like to push you around.
But against Baltimore in the preseason opener, the unit struggled. On top of that, starting guard Alex Boone continues to hold out.
This makes for an interesting test for the Broncos, as becoming more physical on defense is the key to the 2014 campaign.
Defensive tackles Terrance Knighton, Sylvester Williams and Marvin Austin will be the players to watch for Denver. If they are able to muscle the San Francisco offensive line around, it will be very encouraging.
Denver Secondary vs. Anquan Boldin and Vernon Davis
Anquan Boldin presents an exciting matchup for the revamped secondary in Denver. If you want a physical receiver, they don't come any more physical than Boldin.
He is big, strong and tough to tackle.
Tight end Vernon Davis is similar to Boldin, but he is much quicker. The 49ers love to use him in the vertical passing game. Seeing him matched up against T.J. Ward could be a treat.
It will be key for the Broncos to slow these two down.
Brandon Marshall vs. Colin Kaepernick
If Brandon Marshall is truly going to replace Danny Trevathan, he must be versatile. Stopping a quarterback like Colin Kaepernick requires a defense to be versatile.
Kaepernick is one of those quarterbacks who can beat you with his arm or his legs, and Marshall may be asked to stay in and "spy" Kaepernick on passing downs. Kaepernick is very versed at tucking the ball and running with it.
In coverage, Marshall may be asked to step in and defend the 49ers' intermediate passing game, something they are very good at.
Broncos' X-Factor Player of the Week: Juwan Thompson
This is a name Broncos fans are going to hear more and more of. Thompson showed flashes of being a terrific find as an undrafted free agent last week, running the ball six times for 59 yards.
He should see a fair share of carries in this game, and hopefully, fans are treated to his ability as a receiver. He may be the best running back on the team at catching passes out of the backfield.
Thompson was considered a fringe player to make the roster when training camp began and was likely looking at the practice squad as a best-case scenario.
After his performance on Sunday, it will be clear that he makes the final roster, possibly even as the No. 3 running back.