England took a 2-1 lead in the five-match Test series with India after a dramatic victory inside three days at Old Trafford.
The tourists were skittled for 161, as they lost nine wickets after tea, to suffer a crushing innings and 54 runs defeat.
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England, who have bounced back from going 1-0 down in the series, had earlier made 367-9 in their first innings in Manchester with Joe Root (77) and Jos Buttler (70) sharing a 134-run partnership.
The hosts were without Stuart Broad after he was forced to retire hurt after being struck in the face by a Varun Aaron bouncer while batting.
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However, they shrugged off his absence with off-spinner Moeen Ali taking 4-39 in a collapse reminiscent of their struggles in the first innings on Thursday when India made just 152.
After going to tea on 33-1, following the loss of Murali Vijay who was trapped LBW by Chris Woakes, India added 20 more runs before losing five wickets for 13 runs in less than five overs.
Jimmy Anderson picked up two wickets with Ali taking three before making it four when he had Indian captain MS Dhoni caught at mid-wicket to leave the tourists floundering.
Ravi Ashwin made a brisk unbeaten 46 but a comical run out and two Chris Jordan wickets in consecutive deliveries sealed a commanding victory.
The fifth and final Test starts at The Oval on Friday.