The Major League Soccer outfit last met the Gunners in 2011, travelling for that summer's Emirates Cup, where they earned a 1-1 draw against their hosts, and they're hoping to go one better three years down the line.
For Arsene Wenger's side, though, this is a more important fixture in terms of developing steam ahead of the 2014-15 campaign, with some minnows within the squad hoping to seize their chance in New Jersey.
Although he was born in Germany's capital and brought up in the Hertha Berlin academy, Gedion Zelalem moved to the United States at the age of nine and revives a link to his past this week.
Raised in the nearby state of Maryland, it's likely that the 17-year-old will be afforded some playing time on Saturday, having impressed in last weekend's 2-0 win over Boreham Wood, per Bleacher Report's James McNicholas (aka Gunnerblog):
Wenger's fierce beliefs in developing the youth makes the Emirates Stadium as promising a place for a youngster of Zelalem's talent to grow in as any, and the teenager is already showing vast potential in one day becoming a member of the starting XI.
Young though the midfielder might be, this preseason could lend itself in seeing him either remain at Arsenal with first-team action in mind, or perhaps even farmed out for the same intent. In either eventuality, Saturday provides Zelalem with another chance to convince.
Mathieu Debuchy may have signed on the dotted line, but Arsenal's shiny new right-back hasn't made it for the journey to Harrison, New Jersey, meaning that Carl Jenkinson is likely to deputise in his stead.
Wenger's most recent purchase will take the position as first choice in the position this term, meaning that Jenkinson will snap at any playing time afforded, which the Mirror's John Cross says should come away from the Emirates:
Despite never gaining genuine prominence in the club's starting XI, Jenkinson does have promise about him, as WhoScored shows:
The Red Bulls are a good test to impress against; weak enough that a trimmed-down Gunners squad such as this can experiment but strong enough to say that any impacts made are well-earned, too.
The only recognisable striking figure in Wenger's squad for Saturday's outing, Chuba Akpom may find himself starting against the Red Bulls after impressing as a half-time substitute against Boreham Wood.
The speedster's mazy dribbling was unsurprisingly at the core of his display, with Football Vines very rightly praising one piece of skill in particular:
Of course, it would be folly to suggest playing time is earned by such flash-in-the-pan brilliance, but after loan spells with Brentford and Coventry earlier this year, Akpom may finally be picking his way into Wenger's reckoning.
With the likes of Olivier Giroud, Yaya Sanogo and Alex Oxlade-Chamberlain all absent, the 18-year-old will be happy to feature at any interval, and even if another loan away is the best Akpom may hope for this season, those hopes can be helped should he succeed against the New Yorkers.