Screenshot of MFL via Andrew Garda
MyFantasyLeague is a fully customizable management site.
Nobody has been able to challenge ESPN, Yahoo, NFL or CBS in terms of popularity when it comes to hosting fantasy leagues.
A lot of that has to do with name recognition, although in some cases price (free!) helps.
But you have some other options which are worth looking into.
MyFantasyLeague.com has a fully customizable look and format. You can give your league a personality with different color schemes, logos and scoring, and the site usually has some decent deals for buying the service.
I've always liked MFL, though I've seen leagues which from a "look" point of view were too busy for my tastes. I've never had issues with the service, though, which is always a plus.
RTSports.com has fewer bells and whistles but is a very solid choice for hosting your league. It has branched off into baseball for full-on fantasy play as well, so if you happen to play both, it's good to have all your leagues in one place. RTSports does daily games as well, adding basketball and hockey into the mix.
The more interesting idea I've seen is via a site called Fanium.com, which is a mobile app-based league-hosting service.
Basically you do everything on your phone. That makes it less customizable but easier to handle managing your team on the road.
I haven't used this service yet but have heard some good things about it.
So if you're tired of the big corporate places, you have some other options to use for your league this season.