If ever there was ever a way to etch your name into Manchester United folklore, then it is by scoring the winning goal against Manchester City after rejecting the chance to sign for them in the first place.
This is exactly what Van Persie did in December 2012, following City's comeback from two goals down.
A soft free-kick was awarded deep into injury-time just on the edge of City's penalty area. As soon as Van Persie stood ominously over the ball, you just had the feeling something memorable was about to happen.
The Dutchman curled the ball past the wall, with the aid of Samir Nasri's right boot, into the far corner of Joe Hart's net, to spark joyful celebration amongst the travelling United support behind the goal.
This moment was vitally important, as it gave Manchester United an edge in the title race with the Reds going six points clear at the summit of the Premier League table.
However, what made this all the more sweet for Manchester United supporters was the interesting back-story which had led Van Persie to United.
It was reported by James Phillips of the Mirror that Van Persie had turned down an offer from Manchester City in order to join United.
At a time when Manchester City could, and possibly still can, offer a far greater financial package to potential new signings than United, Van Persie turning the money down in favour of working with Sir Alex Ferguson felt like a significant victory for sporting history and tradition in the eyes of the Old Trafford faithful, and it endeared Van Persie to the Stretford End rather more quickly than most.
From a wider perspective, this injury-time winning goal gave the United squad the belief that they once more had a true match-winner in their ranks.
Since the departure of Cristiano Ronaldo in 2009, game-changing players have been few and far between at Old Trafford. But Van Persie was exactly that.
Following the disappointment of losing the title to City the previous season, it would have been easy for United to fold into their shell. But Van Persie wouldn't let that happen and was determined to drag United over the line at times.
The free-kick against Manchester City was, however, only a mere glimpse of the genius which was to follow for the remainder of the season.