Indeed, the squad is filled with stars on both sides of the ball, but it's also jam-packed with potential, especially after San Francisco added 12 players in the 2014 NFL draft.
However, San Francisco is set to be without injured inside linebacker NaVorro Bowman for much of the campaign and may also be forced to play games with outside 'backer Aldon Smith on the sidelines, depending on the results of the legal proceedings against him, meaning that it will be even more important for some of the Niners' defensive reinforcements to step in and contribute.
Additionally, there promises to be fierce competition in a secondary that was depleted by the losses of Donte Whitner, Tarell Brown and Carlos Rogers but that saw first-round pick Jimmie Ward arrive as one of four defensive backs taken by the 49ers in the draft.
Playing time on both sides of the trenches and at the running back spot will also be heavily sought after, with players looking to deliver their best in the hope of attaining a good chance of earning a starting berth in the future.
More often than not, competition and pressure bring out the best in players, and the 49ers will be keen for a few of their lesser lights to respond to the battle for more game time by producing breakout performances at the highest level in 2014.
Here, I look at the five 49ers most likely to do just that in the upcoming season.