Nemanja Vidic and Rio Ferdinand have already confirmed they will leave Old Trafford this summer.
But they might not be the only ones.
The new manager will be tasked with turning around the club's fortunes. That means strengthening the squad with new arrivals but also letting some players leave.
Patrice Evra and Ryan Giggs are out of contract with announcements on their futures yet to be made.
Other members of the squad have had poor seasons and might find themselves surplus to requirements when a new man takes over.
Here's a list of six United players who could be on their way out this summer.
Feel free to use the comments section below to add your own.