Real Madrid will be looking to take advantage of a Valencia team coming off a demoralising Europa League loss as Los Blancos look to keep up with Atletico Madrid and Barcelona in the race for the La Liga title, hosting the Bats on Sunday.
Real trail Atletico by six points with a game in hand but could be running out of time as just three matches separate their city rivals from the title.
Valencia, meanwhile, came very close to another miraculous comeback win over Sevilla in Thursday's Europa League semi-final but fell victim to a last-minute goal, and with Los Che having already dropped out of the race for La Liga's top six, now would be the time for Real to strike.
Date: Sunday, May 4
Time: 8 p.m. BST/3 p.m. ET
Venue: Estadio Santiago Bernabeu, Madrid
Two first-half goals had Valencia believing they could do the impossible and score another comeback win against Sevilla, having previously taken out FC Basel in similar fashion in the Europa League quarter-final.
Stephane Mbia's stoppage-time goal decided otherwise, however, and with nothing left to play for in La Liga, Los Che's season came to a screeching halt.
Paco Alcacer was suspended for the match against Sevilla following Sevilla-stopper Beto's blatant act of simulation, and Squawka underlined his importance to the team by sharing this statistic:
The young striker will be rested for his team's trip to the Bernabeu and will once again provide his team with their best chance of scoring goals, having scored 13 already this season, via WhoScored.com.
But Los Blancos will test Valencia's defence from the very first minute, as Los Che are the only team in the Spanish top eight to sport a negative goal difference, per WhoScored, while Real lead all Spanish teams in scoring with 98 goals in total.
Real scored a huge 4-0 victory over European champions Bayern Munich in midweek and will play their city rivals, Atletico, in the Champions League final later this month, and no team in football has momentum more on their side than Los Blancos.
According to Marca, via Real Madrid Info, Croatian midfielder Luka Modric's availability for this match is a question mark, but no other fresh injuries have befallen the team since midweek.
Cristiano Ronaldo looked every bit as fast against the Bavarians as he did before injuring his hamstring last month, and the Portuguese superstar should be able to start on Sunday.
While Carlo Ancelotti will no doubt want to keep his players healthy for the final few weeks of the 2013-14 season, Valencia are one of the last big hurdles left on the team's schedule, so expect Real to field their strongest possible squad.
Atletico and Barcelona will still face each other on the last day of the La Liga season, so Real are still very much alive in the race for the Spanish title. Having already won the Copa del Rey and having qualified for the final of the Champions League, Los Blancos will not let the chance to win the treble out of their sight.
And while La Decima will no doubt hold priority at this point of the season, Real's complete focus will be on the task at hand—beating a Valencia squad coming off an emotionally draining loss.
With European qualification no longer possible through La Liga, Los Che had put all of their hopes on the Europa League, and to have battled so hard and come so close only to lose in the final minutes will have its effect on the team.
Alcacer's unjust ban already had the fans and the team in an odd place emotionally, and the hangover of Thursday's loss combined with that perceived injustice could turn this into a very ugly match indeed.