The Toffees began in calamitous fashion, gifting their hosts a goal with barely a minute on the clock.
Rickie Lambert's teasing cross seemed to flummox Antolin Alcaraz, who diverted the ball past a hapless Tim Howard.
Half an hour later and the same scenario repeated itself, this time with Seamus Coleman nudging a Nathaniel Clyne cross into his own net.
Two goals conceded and both without a Southampton player even shooting—the Toffees never recovered and slumped to just their seventh league defeat of the season.
Here's a look at some Everton-related talking points to emerge from this loss.