Liverpool top the table, while Chelsea need a victory to give them any hope of potentially finishing above them.
Neutrals couldn't have hoped for a more vital game at this stage of the campaign, but as ever, the buildup has been tinged with an air of controversy.
Chelsea face Atletico Madrid in the second leg of their Champions League semi-final a few days later, and with injuries stacking up Jose Mourinho may field a weakened team at Anfield to preserve his side's chances in Europe.
It's par for the course where Chelsea and Liverpool are concerned. It's a rare occasion when these teams meet and there isn't a major talking point—good or bad.
Ahead of the Anfield showdown, we look at 10 of the most memorable moments between Chelsea and Liverpool.