Kickoff time and network: Sunday, Nov. 30, at 1 p.m. ET, on Fox
The Indianapolis Colts had a few baffling losses last year, with two coming at home against Miami and St. Louis. So while Indianapolis is likely to be favored for this highly anticipated battle between the top two picks from the 2012 draft, expect this to be a close game.
Indy can get pressure on the quarterback and defend the pass quite well, but this is a defense that surrendered a shabby 4.5 yards per carry last season, and since coming into the league, Alfred Morris has more rushing yards than every back in the league not named Adrian Peterson. So the 'Skins have the ability to control the pace here and come away with an upset.
The question, of course, is whether that D can slow down Andrew Luck and his stellar group of receivers. They'll need Orakpo, Ryan Kerrigan, Hatcher and the rest of the front seven to come up big with pressure, because that was Luck's Achilles' heel in 2013.
The former top pick completed only 44.1 percent of his passes under pressure last year, according to Pro Football Focus (subscription required), which ranked 22nd out of 27 qualifying quarterbacks.
Prediction: Colts 27, Redskins 24
They'll lose a tight one to cap a very tough road trip.