Kickoff time and network: Monday, Sept. 15 at 8:30 p.m. ET on ESPN
Can Philly's vulnerable pass defense slow down Andrew Luck and his stellar group of receivers in what could very well be Luck's breakout season? It won't be easy, but the key is to dial up some pressure against Luck, who completed just 44.1 percent of his passes under duress last season, per Pro Football Focus (subscription required). That ranked 22nd among 27 qualifying quarterbacks.
Of course, the problem is that Philly had a sack percentage of just 5.2 last year, ranking last in the NFL. Trent Cole is aging, and the Eagles didn't do much in free agency to improve the pass rush. Maybe the draft will bear fruit in that area, but right now it makes for a poor matchup on that side of the ball.
The good news is that Indy's defense still has its exploitable areas, particularly on the ground. And Kelly's high-octane offense, which led the NFL in rushing last season, could have a chance to do some serious damage, especially on the ground.
On the road, this'll be a tough one, but the running game should keep the Eagles in it.
Prediction: Colts 30, Eagles 23
Tough break with Indy's home opener on prime time.