The Red Wings finished the season on a 6-2-1 hot streak, but still looked fragile from time to time, as they struggled to put some games away.
The Bruins, meanwhile, used a 12-game winning streak in March to run away with the Eastern Conference title, eventually winning the Presidents' Trophy as well.
But the Bruins went 2-2-3 over their last seven games, showing they are in fact human. With Detroit being the only team that has beaten the mighty Bruins three times this season, this should be quite the series.
Here are the five biggest questions for the Detroit Red Wings in their first-round series against the Bruins.
Note: "Biggest" in this context, means most likely to result in a series win for either team.