Pacquiao is favored but has lost two of his previous three fights. Not to mention his Hall of Fame trainer Freddie Roach has admitted that retirement would be a possibility if he were to lose this weekend, per The Telegraph's Gareth A. Davies:
This is a 'must-win' situation on Saturday night, and if we don't win this fight we have to consider maybe retirement. So this is a big, big fight for him. We are in a 'must-win' situation, it's as simple as that. Some people think we are all done and we have to prove that we are not.
Across the ring, Bradley is looking to remain perfect and retain his WBO welterweight championship. But, more importantly, the American known as "Desert Storm" is eyeing redemption following 2012's controversial victory.
While many have already settled on their favorite for the rematch, there are plenty across Twitter who have yet to make a prediction. And the reason is simple: Both fighters are evenly matched:
Even ESPN boxing writer and commentator Dan Rafael is unsure heading into Saturday's bout:
Others, like former unbeaten South African southpaw Chris van Heerden, have Pacquiao avenging his 2012 loss:
Twitter user Ralph Warren gives "Pac-Man" the edge as a result of his superior power:
Eddie EJ Mullins on Twitter predicts a similar style of fight to the first matchup in 2012 but believes Pacquiao will wind up on the winning end of a judges' decision:
Some have also brought the revenge factor into play:
It's hard to argue against either fighter in this bout, especially Pacquiao, who landed 190 power punches in the first fight compared to just 108 for Bradley.
Despite that figure, some are leaning towards Bradley this weekend:
Twitter user Adrian Perez isn't sold on Pacquiao winning either:
Boxing Mad Magazine editor James McKnight predicts an identical result with Bradley earning yet another split-decision victory over Pacquiao:
Although we'll have to wait until Saturday night to know for sure, the result of Pacquiao vs. Bradley II is guaranteed to have a massive impact on the boxing universe.
With Roach labeling the bout a "must-win" for Pacquiao, this could be the last time boxing fans have an opportunity to see one of the best in action.
On the other hand, this fight is critical to Bradley's legacy as well and will certainly impact where he's ranked among the sport's elite fighters. And with a perfect record and a championship belt on the line, Bradley has every bit as much to lose this weekend.
Follow Bleacher Report Featured Columnist Patrick Clarke on Twitter.