David Moyes will be hoping his Manchester United side can take some momentum from their impressive midweek display against Bayern Munich and see off Newcastle at St James' Park on Saturday.
The Red Devils came away from Tuesday's home first-leg quarter-final clash against the Bundesliga champions with a 1-1 draw which leaves them with a chance of qualifying for the semi-finals on Wednesday.
Moyes has a tricky team selection to decide on, as he will be aiming to keep some players fresh for their visit to the Allianz Arena.
Meanwhile, Newcastle will be looking to bounce back from their 4-0 away defeat to Southampton last time out.
When: Saturday, 5 April, 3 p.m. BST, 10 a.m. ET
Where: St James' Park, Newcastle
TV Info: NBCSN (U.S. only)
Live Stream: NBC (U.S. only)
United looking ahead
Moyes' side have had a woeful season in the Premier League and currently lie seventh in the table.
They are not going to make the top four, and with six games left, it is unlikely that they will move any further down the table as eighth-placed Southampton are six points back.
Thus with little to gain in the Premier League and a huge game to come in midweek against Bayern, it is a fairly safe bet that there will be personnel changes.
The likes of Nemanja Vidic, United's goalscorer against Bayern, and Rio Ferdinand will almost certainly sit this match out.
The big call is whether Wayne Rooney will be kept on the sidelines. He has been United's best player this season and is in cracking form in the Premier League; he has six from United's last six outings, per BBC Sport.
He will also likely be eager to respond on the field to recent comments made about his quality and professionalism by QPR midfielder Joey Barton who said, as reported on Sky Sports:
Rooney could have been world class but look at his mentality compared to Cristiano Ronaldo. Polar opposites.
Why does Ronaldo achieve what he achieves and Rooney doesn't?
When you see Wayne Rooney smoking cigarettes, does he live his life correctly?
Quite surprisingly, the Red Devils actually have the best away record in the league, having picked up 30 points from 16 games on the road this season, per ESPN FC.
While they will certainly be looking to maintain that record in Newcastle, it would not be surprising if the likes of Javier Hernandez, who scored from the bench in last week's 4-1 win over Aston Villa, gets a starting role.
Newcastle on the beach
It is no exaggeration to say that Alan Pardew's men have had a dip in form lately. Three losses in four games, one of those to bottom-of-the-table Fulham, does not represent a good return.
However, their mid-table position leaves them with very little to play for this season, and it is unsurprising that some of the squad may already be looking to their summer break.
But the Newcastle faithful will not accept another lacklustre display, especially if there is an opportunity to turn over a potentially under strength United side.
A look at their performance against Southampton shows that they are lacking ideas. This stat, via Opta Joe, illustrates their lack of intent:
Their top scorer Loic Remy, who has 13 league goals this season, per BBC Sport, has been ruled out for Saturday's game, as reported by the Chronicle's Lee Ryder:
Without their main goal threat, Newcastle could really struggle even against a weakened Manchester United side, as they have been struggling to find the net of late, even while Remy was in the side:
With the injuries mounting at Newcastle, another loss on Saturday and fans and players alike may be counting down the days to the end of the season.
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