Tuesday's Champions League quarter-final first legs both finished on a knife-edge, so can any of Wednesday's four teams establish the type of advantage Bayern Munich, Barcelona and Co. failed to muster?
Both matches will kick off at 7.45 p.m BST (2:45 p.m. ET), with the return legs set for Tuesday, April 8.
Real Madrid v Borussia Dortmund
Real Madrid and Borussia Dortmund will resume one of Europe's newest rivalries when Die Borussen visit the Bernabeu on Wednesday.
The German squad eliminated their hosts from the competition in last year's semi-final, and Real will be more than keen to extract revenge on the Schwarzgelben.
Star forward Cristiano Ronaldo couldn't hide his enthusiasm when the draw was made official:
Los Blancos have looked phenomenal at times in this year's competition, and they have their eyes set on a double swoop with the Spanish La Liga title race also going down to the wire.
A big win over city rivals Rayo Vallecano last weekend has the team feeling confident once more after losses to Barcelona and Sevilla, and Carlo Ancelotti's men have to feel confident going into this tie.
Dortmund have struggled through a campaign littered with injuries and bad luck, and the fact they have made it this far is a credit to the quality of Jurgen Klopp's squad. While Real will be heavily favoured going into this tie, the visitors have shown time and time again they have a knack for overcoming adversity.
As shared by WeAreMadrid10, Robert Lewandowski will miss this match due to suspension:
Without the Polish international to provide the goals, Die Borussen will be counting on Marco Reus to provide most of their danger. But with the return leg at the Signal Iduna Park, where Dortmund can count on their fantastic fans to make the difference, defending should perhaps be the team's main concern on Wednesday.
PSG v Chelsea
Live stream: Mobile coverage will be available via the Sky Go app (subscription required) and the Fox Sports app.
With the Ligue 1 title race all but over, PSG have been able to fully focus on this tie against one of Europe's most consistent performers on the European stage.
Les Bleus have yet to deliver on all the promises made when the club went through an extensive financial takeover, but this could finally be the season in which the club establishes itself as a global superpower.
Standing in its way is one of football's finest coaches in Jose Mourinho, and a Chelsea team that has shown it can rise up to the challenge when needed. The visitors have been great going up against some of the Premier League's top sides, beating Manchester City, Liverpool, Arsenal and Manchester United this term, yet have often struggled to put away smaller teams.
Losing to Crystal Palace only to travel to the French capital and surprise PSG would fit this season's playbook perfectly, and it's a scenario everyone on the Blues' bench would settle for.
All eyes will be on star striker Zlatan Ibrahimovic, as he sets out to spearhead PSG's attack. In response to the player's statement that he didn't plan on ever playing in the EPL (as reported by The Telegraph's Matt Law), Jose Mourinho gave Zlatan the perfect mix of respect and sarcasm, per Chelsea's official Twitter feed:
Both have shown an affinity for the cameras, but Mourinho and Ibrahimovic are also known to do much of their talking on the pitch. Fans can only hope both deliver.