Four games are all that separate this year's eight remaining Champions League contenders from the May 24 final in Lisbon.
Each team left in the competition was a group winner back in December, an indication of the quality on offer as the quarter-finals arrive, and a first per ESPN FC:
Tuesday and Wednesday see all four first legs take place, with Manchester United, Barcelona, Real Madrid and PSG all looking to make use of home advantage.
Read on for a full fixture list as well as live streaming information and first-leg predictions.
|Champions League 2014: Quarter-Final First-Leg Fixtures|
|Date||Time||Fixture||Live Stream Info||Prediction|
|April 1||7.45pm BST, 2.45pm ET||Barcelona vs. Atletico Madrid||Sky Go app||2-1|
|April 1||7.45pm BST, 2.45pm ET||Manchester United vs. Bayern Munich||ITV Player||1-2|
|April 2||7.45pm BST, 2.45pm ET||Paris St-Germain vs. Chelsea||Sky Go app||2-2|
|April 2||7.45pm BST, 2.45pm ET||Real Madrid vs. Borussia Dortmund||Sky Go app||3-1|
Moyes Faces Biggest Challenge Yet
Manchester United host reigning European champions Bayern Munich on Tuesday evening and, in terms of the quality of the opposition, it marks perhaps the biggest challenge of David Moyes' entire career.
The former Everton boss has not fared well against big sides in the Premier League this season, the Red Devils having endured heavy losses to Liverpool, Chelsea and Manchester City.
However, Moyes has done better in the Champions League. The 2-0 last-16 first-leg defeat to Olympiakos aside, United have had good results in Europe, including two thrashings of Bundesliga side Bayer Leverkusen in the group stages.
But Pep Guardiola's Bayern outfit present a formidable challenge. Last week saw them wrap up the Bundesliga title with seven games to spare, per BBC Sport.
Their only loss in Europe this season came against Manchester City in the group stages when the German side had already safely qualified.
Meanwhile, United are seventh in the Premier League and will not qualify for the Champions League next season unless they can somehow win the competition. The two teams are seemingly worlds apart:
Despite the perceived gap in quality, Old Trafford veteran Ryan Giggs believes his colleagues can claim victory in Tuesday's match, as reported by Sky Sports:
As players we don't see ourselves as underdogs, we see ourselves as Man Utd playing at home in the Champions League and we can't wait.
These are the games that you want to be involved in as a player and we will go out there and try and win the game. It is going to be tough but it usually is in the quarter-finals of the Champions League and we are confident.
United will be without Robin van Persie, whose hat-trick propelled them to victory in the last 16.
However, the Red Devils arguably meet Guardiola's men at a good time after Bayern's 16-game winning streak came to an end as they drew 3-3 with Hoffenheim at home.
Moyes' side will need to take a lead to the Allianz Arena if they are to have any chance of making it through to the semi-finals.
But with the tremendous strength and depth in the Bayern squad, it seems highly unlikely that United will claim a victory.
Madrid Out for Revenge
Real Madrid were dumped out of the Champions League last season in a 4-3 aggregate loss to Borussia Dortmund at the semi-final stage.
The two sides meet again in this year's quarter-finals and, as Carlo Ancelotti's side stutter in the La Liga title race, Madrid will have extra motivation to atone for the mistakes of last term.
Jurgen Klopp's Dortmund have already lost the league to Bayern Munich and will thus be looking for a good showing in Europe.
However, Dortmund have not been quite the same side this term, while Madrid have eased through this year's Champions League have yet to lose in the competition.
Madrid come into the game in stuttering league form having lost two of their last three games domestically. But they did defeat Rayo Vallecano 5-0 last time out and Cristiano Ronaldo will be looking to put himself into the Champions League record books, per ESPN:
Madrid will likely have the power to overcome last year's beaten finalists, especially as Wednesday's game is being played at the Bernabeu.
A convincing win over Dortmund could reignite their season as they attempt to move one step closer to that elusive 10th European title.
And after last year's ignominy, Madrid have the ultimate motivation to put one over on the German side.