Both Gerard Pique and Diego Costa were forced off on Tuesday night.
Per Marca, Diego Simeone had noted in the day before this game that it was unlikely Diego Costa would play any part.
Was it therefore sheer stupidity to place him in the starting XI or a risk worth taking?
After 28 minutes play, Costa was forced off with a hamstring injury that could well rule him out of the return, so you would have to conclude it was the former.
With such reliance across the season on their big front-man, has Simeone scored a real own-goal here?
Gerard Pique fell awkwardly when challenging Costa, and looked uncomfortable as he limped off.
His performances this season alongside Javier Mascherano have drifted between comical and magnificent, but he does remain Barca's first choice centre-back.
Marc Bartra's excellence when called upon is becoming a familiar theme, and again here he showed that he is one for the future. Perhaps even one that is ready to take up a permanent residency in the Barca defence now.
It's arguable therefore that Atleti will feel the loss of their man that bit more than the Blaugrana.