The Partenopei's title challenge has long since burned out, while Juve have relentlessly stormed to, in all probability, a third successive title.
Rafael Benitez's side know there is still plenty riding on the game, however, even if the Azzurri go into the match seeking a win for entirely different reasons.
Benitez is adamant that second in the table should be the goal now, with Roma holding a sizeable advantage to be the best of the rest.
Despite the obvious fact that second is better than third, failure to usurp the Giallorossi will mean that Benitez's side will face a Champions League qualifier at the very beginning of next season, something that is never ideal when preparing the squad during pre-season.
The Old Lady have different challenges left to fulfill this season, even if they continue to insist the title race is not over.
Antonio Conte's side are set for a record points total in Serie A and they will see Napoli as a stepping stone to this.
There is also the small matter of both sides gaining a psychological edge for the start of next season, with Napoli surely looking to hold together a more sustained title challenge.