Arsenal play host to Manchester City on Saturday in the biggest game of the Premier League weekend.
The Gunners are looking to force their way back into the Premier League title race after the six-goal drubbing at Chelsea and the 2-2 draw with Swansea at the Emirates Stadium on Tuesday.
But City are looking to keep breathing down the necks of leaders Chelsea with a win in North London.
Liverpool are also in the title hunt and will entertain Tottenham Hotspur on Sunday, while Champions League outsiders Everton travel to Fulham on the same day.
Leaders Chelsea make the short trip across the River Thames to Crystal Palace, while beleaguered Manchester United entertain Aston Villa in the Saturday lunchtime kick-off.
Here's a rundown of the latest team news.
Manchester United vs. Aston Villa
Manchester United are still without striker Robin van Persie, while Chris Smalling and Jonny Evans remain doubtful. Nemanja Vidic returns after suspension.
Charles N'Zogbia is still out for Aston Villa, and Andreas Weimann and Karim El Ahmadi are doubts.
Crystal Palace vs. Chelsea
Marouane Chamakh and Dwight Gayle remain sidelined for Crystal Palace.
Chelsea will be without Samuel Eto'o and Ashley Cole, while Ramires is still suspended. Willian returns from suspension.
Southampton vs. Newcastle United
Steven Davis is out for Southampton, while Nathaniel Clyne, Jay Rodriguez, Morgan Schneiderlin and Victor Wanyama face late fitness tests.
Tim Krul and Loic Remy are out for Newcastle, but Davide Santon has returned to fitness.
Stoke City vs. Hull City
Robert Huth is still out for Stoke, while Jon Walters is banned. Oussama Assaidi and Erik Pieters face late fitness tests.
Hull goalkeeper Allan McGregor has joined Robbie Brady and Paul McShane on the long-term casualty list.
Swansea City vs. Norwich City
Swansea City have no fresh injury concerns, with Kyle Bartley the only absentee.
Norwich City defender Michael Turner could return, but Elliott Bennett and Leroy Fer are still out.
West Bromwich Albion vs. Cardiff City
West Brom have a doubt over Victor Anichebe but Gareth McAuley is fit. Jonas Olsson is still suspended. Morgan Amalfitano and Diego Lugano could return for Albion.
Craig Noone and Andy Taylor are rated doubtful for Cardiff, but Mark Hudson could return.
Arsenal vs. Manchester City
Aaron Ramsey, Mesut Ozil, Jack Wilshere, Theo Walcott and Laurent Koscielny are all out for Arsenal.
Sergio Aguero and Matija Nastasic will miss out for Manchester City, while David Silva faces a late fitness test.
Fulham vs. Everton
Fulham will be without striker Kostas Mitroglu and midfielder Scott Parker, but Ashkan Dejagah returns to the squad.
Steven Pienaar is still out for Everton along with long-term casualties Bryan Oviedo, Darron Gibson and Arouna Kone. Phil Jagielka returns from injury.
Liverpool vs. Tottenham Hotspur
Liverpool have no fresh injury concerns, and defender Jose Enrique remains sidelined.
Emmanuel Adebayor is set to return for Tottenham, but Kyle Walker and Vlad Chiriches are out.
Sunderland vs. West Ham United
Sunderland have no fresh injuries, and striker Steven Fletcher is still out.
James Collins and Matt Jarvis are rated doubtful for West Ham, who will still be without Joey O'Brien.