The most hyped of the eight games being played in the Sweet 16 comes from Indianapolis, as No. 4 Louisville faces No. 8 Kentucky on Friday night at approximately 9:45 p.m. ET.
The game will be one of the most intense in the history of the rivalry, as an experienced Louisville side will take on a young Kentucky team with a spot in the Elite Eight on the line.
The two sides met on December 28, and it was Kentucky that pulled off the win at Rupp Arena.
For Louisville to avenge that loss and move one step closer to repeating as national champion, it will have to surpass these five challenges.