Virginia enters its battle with Michigan State with an Atlantic Coast Conference regular-season championship and tournament title on its 2013-14 resume.
According to VirginiaSports.com, UVa (30-6, 16-2 ACC) is "one win shy of breaking the school record for most victories in a season."
The Spartans are no stranger to the Sweet 16. Under head coach Tom Izzo, MSU has advanced to the second weekend of the NCAA tournament 12 times in 18 years.
The Cavaliers, on the other hand, have only made 18 NCAA tournament appearances, with seven trips to the Sweet 16, in school history.
It is strange that, Tony Bennett's squad, a No. 1 seed, may go into its contest with Michigan State as an underdog.
Here are five challenges the Cavs will tackle when they face the Spartans in their Sweet 16 matchup.