Gus Poyet's men sit just a point off of the foot of the table and with only one win in their last six per WhoScored.com.
The last thing they need is to be facing the highest scorers in the division:
The home side have no bigger incentive to continue their sparkling form; a win in this one will take Liverpool to just a point behind league leaders Chelsea.
Date: Wednesday March 26
Time: 8 p.m. GMT/4 p.m. ET
Live Stream: SkyGO app (UK only)
TV Info: Sky Sports 1 (UK), NBC Sports Network
There are two names guaranteed to strike fear into any Premier League defence: Luis Suarez and Daniel Sturridge.
The Liverpool duo are the top two scorers in the Premier League and their 47 goals are better than 15 out of the 20 Premier League teams entire total.
Sunderland's pathetic tally of 26 is two worse than Suarez's individual total, per WhoScored, so the danger to the visitors is crystal clear.
Both Wes Brown and John O'Shea will need all of their experience to keep the Liverpool attacking threat at bay for the full 90 minutes.
Jordan Henderson, a boyhood Sunderland fan, will bring some steel and bite to the Reds midfield alongside captain Steven Gerrard, but if the returning Lee Cattermole can get a foothold in the match, Liverpool might not have things all their own way.
It was good to see the drive from Lee, that’s why I changed it.
Probably the people who analyse the game think because we were 2-0 down you shouldn't play Lee Cattermole because you need an offensive player, but it wasn't about an offensive player, it was about character, bringing other people into the game and giving me something we didn't have—energy.
That’s what Lee is all about.
It's that sort of performance that the Uruguayan will require from his entire XI if Sunderland want to spring the surprise of the season.
However ex-Liverpool and Sunderland star Don Hutchison thinks the manager is just as much to blame for the Black Cats poor form as his players. Via his column in The Journal he said:
Gus Poyet seems to have lost his way a bit as well. Good players are letting him down but Gus isn't immune.
Every week it’s three or four changes and as a player sometimes you’re scratching your head at that.
Players are getting substituted early in games. He looks like a man trying to find a solution but he’s getting no closer.
Now he’s got the equivalent of the managerial mission impossible on Merseyside tomorrow.
Whilst the Black Cats do still have games in hand on those around them, Poyet's side are dropping like a stone and are running out of games to reverse the slide.
Young Liam Bridcutt, sat alongside Cattermole, can provide the combative presence that Poyet is looking for and heading to Anfield holds no fear for the youngster, per Stuart Rayner of The Journal.
Fabio Borini is ineligible for this match against his parent club, so goalscoring duties for Sunderland fall to a woefully out of form Jozy Altidore.
Just one goal and one assist in his 26 games (eight as sub) per WhoScored, is hardly likely to give Liverpool's back four sleepless nights.
Only five goals for Sunderland in their last 12 visits to Anfield, per WhoScored, is evidence of what a mountain they have to climb to get anything from the game.
Sunderland's best hope of any success may well come via the tricky Adam Johnson. His ability to go both ways past his full-back could see him wrong foot Jon Flanagan, a right-back by trade but covering in the position.
Liverpool should still have enough in the tank to easily see this one out, however, and a win could be the beginning of the end for Sunderland's stay in the Premier League.