The tables have turned in Manchester, for this season at least, with City coming to Old Trafford with hopes of securing points that will contribute to them going top of the table.
In contrast, the only thing United have to play for is stopping City from winning the league. Although, in taking three points off City, United might just be aiding Liverpool's title challenge, meaning any result for the Reds could lead to misery.
After the 4-1 battering away from home, United will be playing for pride, with nothing else at stake for them. But with so many players out injured, what is the best line-up United fans can hope for?