The fact that 12 points and four Premier League positions currently separate Manchester United and Manchester City makes Tuesday's derby a more important one for the latter, but United will be determined to ruin City's championship challenge.
The meeting at Old Trafford might be an uncomfortable one for home fans who still remember the 6-1 drubbing dished out by their rivals in October 2011, and indeed City's 2-1 win on the same stage last season.
But United will at least approach it with some confidence following back-to-back wins over Olympiakos and West Ham which have at least ensured last weekend's 3-0 loss to Liverpool can be forgotten about.
United may have had a tough season under David Moyes, but they still possess plenty of players that clubs around the world would love to have.
So what if we combined the Manchester clubs to form one super-team? Who would be in our starting XI?
In picking our team we've tried to imagine which players would fit best into a 4-2-3-1 formation, meaning that there is no place for the likes of Robin van Persie and Alvaro Negredo despite their obvious talents, whilst we've also gone for experience over youth ensuring that there is no spot for the promising Adnan Januzaj either.
You'll all have your own opinions, so feel free to drop them in the comments box below: