After a midweek of Champions League action, the focus returns to the Premier League this weekend with one of the biggest games of the season on the calendar.
Arsenal make the trip across London to Chelsea, where Gunners manager Arsene Wenger will take charge of his team for the 1,000th time.
Manchester United are also in the capital on Saturday for their match at West Ham, while Liverpool travel to Cardiff City.
Manchester City play host to Fulham, and Everton are entertaining Swansea City. Tottenham Hotspur are at home against Southampton on Sunday.
Here's the latest team news for the forthcoming Premier League weekend.
Chelsea vs. Arsenal
Chelsea will be without Ashley Cole, while Ramires and Willian are suspended after their red cards at Aston Villa last weekend.
Arsenal are without long-term casualties Abou Diaby and Theo Walcott, while Jack Wilshere remains sidelined. Mesut Ozil and Aaron Ramsey are also doubtful.
Cardiff City vs. Liverpool
Cardiff City will be without defender Mark Hudson, and Ben Turner and Andy Taylor are rated doubtful.
Liverpool have no fresh injury concerns, but Jose Enrique remains sidelined.
Everton vs. Swansea City
Everton have doubts over Gareth Barry and Phil Jagielka, while Steven Pienaar, Bryan Oviedo, Darron Gibson and Arouna Kone are all still out.
Swansea City have doubts over Jonjo Shelvey and Nathan Dyer.
Hull City vs. West Bromwich Albion
Paul McShane is a long-term casualty for Hull City, while Robbie Brady also remains sidelined.
Morgan Amalfitano is rated doubtful for West Bromwich Albion, but Jonas Olsson is out.
Manchester City vs. Fulham
Vincent Kompany is suspended after his red card at Hull last week. Sergio Aguero and Matija Nastasic are still out, while Stevan Jovetic and Micah Richards are doubtful.
Dan Burn, Ashkan Dejagah and Kostas Mitroglou are all out for Fulham, while Scott Parker is also absent.
Newcastle United vs. Crystal Palace
Davide Santon and Rob Elliot are doubtful for Newcastle, but Hatem Ben Arfa and Mathieu Debuchy remain sidelined.
Crystal Palace have doubts over Barry Bannan and Danny Gabbidon, but Marouane Chamakh and Jimmy Kebe are both out.
Norwich City vs. Sunderland
Elliott Bennett has returned to training for Norwich after seven months out but is unlikely to feature. Michael Turner and Jonas Gutierrez are also back in training but will miss the Sunderland game.
Steven Fletcher is a doubt for the Black Cats, while Connor Wickham remains on the sidelines.
West Ham United vs. Manchester United
Joey O'Brien and Marco Borriello are the only absentees for West Ham United.
Manchester United could be without Robin van Persie and Antonio Valencia, while Nemanja Vidic is suspended.
Tottenham Hotspur vs. Southampton
Tottenham have doubts over Emmanuel Adebayor, Mousa Dembele, Kyle Walker and Younes Kaboul.
Southampton pair Dejan Lovren and Victor Wanyama are both rated doubtful.
Aston Villa vs. Stoke City
Gabriel Agbonlahor is the major doubt for Aston Villa, but Charles N'Zogbia remains sidelined.
Charlie Adam and Jon Walters are suspended for Stoke, while Erik Pieters and Oussama Assaidi are expected to miss out.