Jose Mourinho's side play their third London derby in their last four league games with another to follow next weekend, and the Portuguese will be keen to continue his astonishing home record as Chelsea manager.
In both spells, he is yet to taste defeat in the league, a record which currently stretches to 75 games.
Step forward Arsene Wenger, who will be keen to ram the "specialists in failure" taunt right back down his throat.
Just four points separate the north Londoners from the summit, and a win here for only the third time since 2004, per 11v11, would really put a dent in Chelsea's hopes of regaining the title, as the Gunners still have a game in hand over their rivals.
Date: Saturday, March 22
Time: 12:45 p.m. GMT/8:45 a.m. ET
There isn't too much doubt as to who holds the better recent record between these two London clubs.
Between 1998 and 2004, the Blues astonishingly didn't win a single game home or away against the Gunners, per 11v11—a full 17 games.
Since then however, the tables have very definitely turned, and Arsene Wenger's men have managed just three wins, the most recent a 5-3 win at Stamford Bridge in 2011.
Per WhoScored, Chelsea have won the last five games in all competitions against Arsenal and have scored at least twice in six of their last seven home matches between the two.
Jose Mourinho's men have also kept a clean sheet in their last four at home.
Per Opta via Bruce Archer of the Daily Mirror, Arsenal are statistically better in most departments than their rivals.
According to the figures published, possession stats are fairly equal across the season, with the Gunners' 55 percent just edging Chelsea's 54 percent.
Arsenal's pass accuracy of 85.2 percent is better than the Blues' 84.3, and perhaps even more interestingly, Arsenal's 20.6 tackle win percentage is better than the home side's 19.9.
Arsenal have often been considered as having a "soft core" and Chelsea more robust; however, the stats suggest otherwise.
Shot conversion rate also favours the North Londoners, 15 percent to 11, and in a sign of the difference in how the two sides play their football, Chelsea continue to utilise the long ball on more occasions, 56.1 percent compared to Arsenal's 45.1.
Only a single loss in the Premier League since Christmas last year for Chelsea gives you an idea of the size of the task that is facing Arsene Wenger's side.
Intriguingly, Arsenal are undefeated in all of their London derbies this season, bar one—against Chelsea in the Capital One Cup, per WhoScored.
Key to Chelsea's run has been the form of both John Terry and Gary Cahill in the Blues' back line.
Terry is enjoying the sort of form that would normally have brought him back into focus for the England World Cup selection committee, but Roy Hodgson has slammed that particular door shut, per BBC Sport.
Can Arsenal end Jose Mourinho's unbeaten record?
To be in with a chance of taking the three points, the Gunners will probably need to score a couple of goals, something that no team has managed since the fixture on December 17 against Sunderland, per WhoScored.
They will also need to ensure that the attacking trio of Oscar, Eden Hazard and Andre Schurrle are not allowed time and space on the ball.
By disrupting their play and energy, it leaves Samuel Eto'o as a peripheral figure up front unable to affect proceedings.
If Santi Cazorla can find room in between the lines, he can open up the channels for the fearless and in-form Alex Oxlade-Chamberlain.
The youngster's direct running can trouble the static Branislav Ivanovic, and if he finds Olivier Giroud centrally, the Frenchman must improve upon his five goals since the turn of the year for Arsenal to be in with a shout.
Prediction: Chelsea 2-1 Arsenal