Tottenham travel to Benfica on Thursday, looking to overturn a 3-1 scoreline after the Portuguese club romped to victory in the first leg of their round-of-16 tie at White Hart Lane.
The visitors bagged three vital away goals, meaning Spurs must find a three-goal advantage over their opponents or match the 3-1 scoreline to have a chance of progressing at Estadio da Luz.
Rodrigo and Luisao did the damage in North London. Now Tim Sherwood must help his team find a response. Here are the key details for Thursday's clash:
When: Thursday, March 20 at 6 p.m. GMT/2 a.m. ET
Where: Estadio Da Luz, Lisbon, Portugal
TV Info: Live on ITV4 and ITV4 HD
Live Stream: ITV Player
No Defence For Spurs
According to Daily Mail's Simon Peach, Spurs could be without any centre-backs for the trip to Portugal.
Younes Kaboul is struggling to make the match as he faces a late fitness test with an unspecified injury, while Jan Vertonghen is suspended.
The Belgian picked up a booking in the first leg, meaning he will be unavailable to take part for Tim Sherwood's men.
Spurs will also be without Vlad Chiriches and Michael Dawson who are both sidelined, and Kyle Walker may miss the match with a groin problem.
Only to add to Sherwood's woes, TheIndySport tweets of more potential casualties:
This could mean a reshuffle of Spurs' pack, with the possibility of playing Sandro at centre-half alongside 21-year-old Ezekiel Fryers.
Tottenham's No. 35 has played five matches in this year's Europa League, per WhoScored.com, so he will be used to performing in Europe for the North London club.
According to WhoScored.com, Etienne Capoue is also a doubt for the match, so 18-year-old Milos Veljkovic could feature.
Veljkovic has yet to play for Spurs in any competition, but with ranks depleted as the side prepare to find out their Europa League fate, it could be the youngster's chance to prove his worth.
Match To Be Won On The Touchline
After the first leg, Sherwood told a press conference of his belief that Benfica coach Jorge Jesus “lacks class,” per BBC Sport.
Sherwood was left unhappy by the manner in which Jesus celebrated his team's third goal at White Hart Lane, appearing to show three fingers at the Spurs boss, confirmed by The Sun's tweet:
The pair will re-unite on Benfica's turf as both look to come out on top and progress into the next stage of the Europa League.
Spurs' boss stated after the first leg, per BBC Sport, that he thought Benfica were an excellent competitor, but lamented his opposite number:
I've got no problem with the attitude or desire. It's just we have to hold our hands up and say they're a class above.
I thought his team were very good, got a lot of class. It's a pity he doesn't. He doesn't mind himself, does he? Waving goodbye like that with three fingers? It lacks class. Why would anyone do that?
However, Jesus said the atmosphere between himself and Sherwood was “pleasant” at the end of the game and that he believed that Spurs' dugouts were too close together:
In Portugal, we have more space apart and we can demonstrate ourselves in our own way. When at some stage I invaded Tim Sherwood's personal space, he told me to go to mine. He did the same to me, but it was no more than that. It was quite pleasant in the end.
The Spurs boss will certainly be hoping that the two sides are closer on the pitch than they were in the first leg, after centre-half Luisao bagged a brace to lift Benfica to victory.
His outfit will have to muster plenty of resolve after the 1-0 derby defeat against Arsenal last time out, with silverware still a possibility this season.
But if they are to manage a win in Portugal, they will have to hope their makeshift back-four defend better at set-pieces, with Luisao knocking at the door once again.