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Crunching the Numbers to Reveal Biggest Potential Upsets in the Midwest Region

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Professor Sheldon Jacobson, a statistician at the University of Illinois, uses 29 years of statistical bracket data to break down, analyze and predict the outcome of March Madness.

For more of Professor Jacobson's work and the real "Bracketology" visit bracketodds.cs.illinois.edu.

Will the Arizona State Sun Devils, a No. 10 seed, come away with the upset victory over the No. 7 seed Texas Longhorns?

What's the likelihood that No. 6 UMass gets knocked out in the second round by the play-in winner of Iowa and Tennessee?

Find out what the professor says, and check out this video before picking your "sure wins."

Comment below with what you think might happen.

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