England take on Italy at Stadio Olimpico looking to build on their Triple Crown success, while the Italians look to avoid yet another wooden spoon.
Jacques Brunel's side have picked up nine last-placed finishes in the tournament's 14-year history, and will be hoping his men can muster a giant-killing against Stuart Lancaster's side.
However, England are looking to bag the title, sitting level on points with France and table-toppers Ireland, with the trio separated on points scored alone.
A fascinating battle that affects both ends of the Six Nations table awaits. Here are the key details ahead of Sunday's encounter:
When: Saturday, March 15, at 12:30 p.m. GMT/8:30 a.m. ET
Where: Stadio Olimpico, Rome, Italy
TV Info: Live on BBC One and BBC One HD
Live Stream: BBC iPlayer
Manu Tuilagi Back For England
It'll be a welcome sight for Lancaster, as Manu Tuilagi returns from his injury lay-off to take his place in England's squad. The combative Leicester centre is one of three changes to the matchday squad, according to the Guardian.
The powerhouse, who can play both as a centre or on the wing, will add a steely resolve to Lancaster's replacements as his side look to close out the tournament with a title win.
Speaking with Telegraph's Mick Cleary, Tuilagi admitted it had been difficult to watch his team-mates in action without him after 12 months out, but stated his excitement to return to action:
This is the longest injury I have ever had. I can’t wait to pull on the shirt again. You see people come back and wonder why they’re charging around in training, so excited. And then I’m like that.
I’ve missed it so much. It is so tough to be out and watching your team-mates perform. Luther and Billy [Twelvetrees] have done fantastically well. It is going to take a lot of work for me to get back in but hopefully I can keep doing what I do and I can be there.
Mako Vunipola has been drafted into the starting XV to face Italy as Joe Marler did not travel to Rome after his partner went into labour.
Matt Mullan also comes onto the bench for the injured Alex Corbisiero, per Independent's Duncan Bech, while Tuilagi replaces Alex Goode among the substitutes.
England Squad To Face Italy (according to BBC Sport):
Brown, Nowell, Burrell, Twelvetrees, May, Farrell, Care, Vunipola, Hartley, Wilson, Launchbury, Lawes, Wood, Robshaw (capt), Morgan.
Youngs, Mullan, Thomas, Attwood, Johnson, Dickson, Ford, Tuilagi.
Parisse Returns To Italy Starting Line-Up
A welcome boost for the sold-out match in Rome, as Italy captain Sergio Parisse is passed fit to play against England after missing last weekend's heavy 46-7 defeat against Ireland with a thigh injury, according to the Guardian.
Parisse's inclusion marks one of three changes to Brunel's side as they chase their first points of the tournament, and as tweeted by Bryn Palmer, the match marks a milestone for the Azzurri skipper:
Parisse captained Italy during their 18-11 defeat by England at Twickenham during last year's Six Nations, and will be looking for a better result this time as he looks to lead his men away from the bottom spot and place Scotland onto the foot of the table.
Italy have also handed a first cap to George Biagi as cover in the second row, named among the replacements, as the Scottish-born Zebre player looks to make his mark on the international side.
Italy Team To Face England (according to the Guardian):
McLean, Esposito, Campagnaro, Garcia, Sarto, Orquera, Tebaldi, Aguero, Ghiraldini, Cittadini, Geldenhuys, Bortolami, Furno, Barbieri, Parisse (capt).
Replacements: Giazzon, Rizzo, De Marchi, Biagi, Derbyshire, Gori, Allan, Masi