But some less celebrated players have also been on the winning side in what is one of the Premier League's most fiercely competitive fixtures.
For every Cristiano Ronaldo, there is a David Bellion. For every Steven Gerrard, there is a Bruno Cheyrou.
In the Premier League era, both teams have signed players that have flopped.
But some of them have a win over United or Liverpool on their CVs.
Here's a list of the 10 worst players to end up on the winning side for United against Liverpool or for Liverpool against United.
There wasn't room for them all, so feel free to add your own in the comments section below.