Updates from Wednesday, March 19
BBC Sport has the latest on Holden's status:
The US international midfielder, 28, first damaged his knee in a tackle with Jonny Evans in March 2011.
Three comeback attempts have ended with Holden suffering further knee injuries but he is determined to play again.
"I am a warrior and that's my mentality. I won't give up because I know I still have a lot left to give the game," he said.
"It's frustrating when you keep asking yourself 'why do you keep having these setbacks? And why is it a big injury after big injury.'
"It was obviously a setback personally and there were a lot of emotions flying around but I'm well and truly feeling like I want to do this thing again."
Stuart Holden's dreams of playing in the 2014 World Cup are officially gone.
Bolton announced the 28-year-old midfielder will be out for approximately six to nine months after he injured his right knee a little over a week ago:
The cruel irony was that that was his first match action since injuring the same knee knee during the 2013 Gold Cup.
Holden is down on the turf again after reaching for a loose ball. Doesn't look good. (26) 0-0 #BOLvEVE— Bolton Wanderers FC (@OfficialBWFC) March 3, 2014
Holden posted a photo of himself post-surgery to his Twitter account:
He shared the contents of an email from a mother whose son's high school career has been beset by much the same injury problems:
This email from a fan is exactly why I will never give up. Every setback and challenge presents a new opportunity. https://t.co/Pk9ip74z5q— Stuart Holden (@stuholden) March 11, 2014
Even if he had been healthy the rest of the season, it was unlikely that Holden would have featured in the first team for the United States in Brazil. The Gold Cup was his best chance to make an impression on Jurgen Klinsmann.
At 28, Holden probably won't have much of a chance to make the 2018 World Cup squad—should the U.S. get that far—either.
While this is likely the end of Holden's national team career, you can bet that he'll be doing everything can just to get back on a football pitch again.