When they meet, the world tends to watch, and the latest clash between Manchester United and Liverpool is sure to be one that will capture attention across the globe.
United boss David Moyes knows that he will earn a lot of forgiveness from his club's fans if he can mastermind a win which will stop the Reds in their tracks, whilst Brendan Rodgers would love to establish a 14-point gap between his side and United as they chase a Champions League place and even unlikely Premier League glory.
But what if both teams were combined? Who would make the cut?
Both teams, and especially Liverpool, possess exciting young talents who have impressed many this season, but in picking our combined United-Liverpool XI we've largely gone for performers who are tried and trusted and have the medal collections to prove it.
That hasn't however extended to picking United's player-coach Ryan Giggs, with a little more youthful energy inserted into our midfield alongside a name who many would have as the first on their teamsheet in Steven Gerrard.
But who is picked in the team along with the Liverpool captain? Take a look through our starting XI: