Despite numerous managerial changes at both clubs—and needless to say a swathe of comings and goings in the player department—West London hasn't been a happy hunting ground for Spurs ever since.
Will that change this year? It looks unlikely, especially given that Spurs have more than their own unenviable record to contend with.
Jose Mourinho remains undefeated in a Premier League fixture at Stamford Bridge, a record dating back to his first season in charge in 2004-05 and an incredible 74 games.
It means the psychological advantage is very much with the Blues, although there will be more than a few mind games at play as both managers attempt to secure victory.
The tactical battle will be just as intriguing in this London derby, so we look at five areas where the game will be won and lost.