Williams finished with 30 points, seven assists, six steals and five rebounds. Pierce added 25 points, seven rebounds and four assists.
Three other Nets reached double-figures, as Joe Johnson, Andrei Kirilenko and Andray Blatche scored 10 apiece.
Pau Gasol led five Lakers in double-figures with 22 points and 11 rebounds.
Kent Bazemore went over the ten-point mark for the second time in as many games with the Lakers, finishing with 17.
Andy Bailey covers the NBA for Bleacher Report.