Patrick Post/Associated Press
Anzhi Makhachkala 0-0 Racing Genk
The hosts had Ilya Maksimov sent off in a scoreless draw.
Chornomorets 0-0 Lyon
The French side were held to a scoreless draw in Ukraine.
Dynamo Kiev 0-2 Valencia
Eduardo Vargas (80') and Sofiane Feghouli (90') scored late goals to give Valencia a valuable away win.
Esbjerg 1-3 Fiorentina
Martin Pusic scored in the first half for the visitors to cancel out Alessandro Matri's excellent opener. But Josip Ilicic and Alberto Aquilani (penalty) scored before half-time to give Fiorentina the victory away from home.
Liberec 0-1 AZ Alkmaar
Nick Viergever scored the only goal for the visitors one minute from full-time.
PAOK Salonika 0-1 Benfica
Lima scored the only goal in the 58th minute.
Ajax 0-3 SV Salzburg
Salzburg stunned Ajax in Amsterdam with three goals in the first half.
Jonathan opened the scoring from the penalty spot in the 14th minute before Sadio Mane doubled the visitors' lead seven minutes later. Jonathan added the third, an audacious strike from the halfway line, 10 minutes before the break.
Porto 2-2 Eintracht Frankfurt
Ricardo Quaresma's golazo put Porto ahead in the 45th minute before Silvestre Varela doubled the hosts' advantage midway through the second half.
But Joselu (72') pulled one back for Frankfurt before the visitors levelled via an Alex Sandro own goal.
Lazio 0-1 Ludogorets Razgrad
Roman Bezjak scored the only goal for the visitors on the stroke of half-time. Ludogorets' Svetoslav Dyakov missed an early penalty, and Lazio's Felipe Anderson missed a spot-kick as well in the second half.
Both teams had a player sent off. Dyakov received his marching orders in the 55th minute, and Lazio's Luis Pedro Cavanda saw red 18 minutes later.
Maccabi Tel-Aviv 0-0 FC Basel
Swiss side Basel, who reached the semi-finals last year, were held to a scoreless draw in Israel.
NK Maribor 2-2 Sevilla
Marcos Magno Morales Tavares and Dare Vrsic scored for Maribor. Kevin Gameiro and Federico Fazio tallied for Sevilla.
Real Betis 1-1 Rubin Kazan
Didac put Betis ahead in the fourth minute, but his goal was cancelled out by Roman Eremenko's second-half penalty.
Viktoria Plzen 1-1 Shakhtar Donetsk
Stanislav Tecl put Viktoria ahead in the 62nd minute, only for Adriano to equalise four minutes later.