Chelsea get the Premier League weekend underway on Saturday when Everton are the lunchtime visitors to Stamford Bridge.
Manchester City play host to Stoke City on Saturday, while Manchester United travel to Crystal Palace in the evening kick-off later on the same day.
Arsenal are at home to improving Sunderland on Saturday, while Liverpool entertain Swansea City on Sunday.
Here's the team news for the forthcoming top-flight matches.
Chelsea vs. Everton
Chelsea captain John Terry will be assessed ahead of the game after a muscle problem. Fernando Torres will be pushing for a starting place after returning from injury.
Romelu Lukaku has returned to full fitness, but is ineligible to play against his parent club. Defender Antolin Alcaraz has overcome a series of niggling injuries to take his place in the squad.
Arsenal vs. Sunderland
Aaron Ramsey, Abou Diaby and Theo Walcott all remain sidelined for Arsenal.
Sunderland defender Wes Brown is suspended, while Carlos Cuellar remains doubtful.
Cardiff City vs. Hull City
Gary Medel misses out with a muscle injury while Craig Bellamy is suspended. Jordon Mutch is rated as doubtful for Cardiff.
Hull defender Paul McShane has been ruled out for the rest of the season after undergoing ankle surgery, but James Chester and Sone Aluko are both available after injury.
Manchester City vs. Stoke City
Manchester City midfielder Fernandinho has recovered from injury, but defender Matija Nastasic is still out. Sergio Aguero is still sidelined, but Samir Nasri will be pushing for a starting berth.
Stoke City defender Robert Huth remains sidelined for Mark Hughes on his return to the Etihad Stadium.
West Bromwich Albion vs. Fulham
West Bromwich Albion are waiting on news of striker Nicolas Anelka, but are likely to be without midfielder Stephane Sessegnon.
New Fulham manager Felix Magath has a doubt over goalkeeper Maarten Stekelenburg.
West Ham United vs. Southampton
Andy Carroll is still suspended for West Ham, but Momo Diame and Joe Cole are available again after injury.
Dejan Lovren has returned to training for Southampton, but the game is likely to be too soon for Gaston Ramirez.
Crystal Palace vs. Manchester United
Crystal Palace manager Tony Pulis could name an unchanged team for the visit of Manchester United, but Glenn Murray could be on the bench after several months on the sidelines.
Manchester United defender Jonny Evans is doubtful with a calf problem, but midfielder Marouane Fellaini is fit again. Winger Nani remains out with a hamstring injury.
Liverpool vs. Swansea City
Daniel Agger and Glen Johnson are both available for Liverpool, and Jordan Henderson could return after wrist surgery. Jose Enrique, Lucas and Mamadou Sakho are still out.
Former Liverpool midfielder Jonjo Shelvey is rated as doubtful for Swansea.
Newcastle United vs. Aston Villa
Loic Remy is back from suspension, while Fabricio Coloccini returns from injury. Cheick Tiote could also return for Newcastle.
Long-term Aston Villa casualties Charles N'Zogbia and Jores Okore remain sidelined.
Norwich City vs. Tottenham Hotspur
Norwich City will be without Jonas Gutierrez and Jonny Howson for the visit of Tottenham on Sunday.
Tottenham have doubts over Emmanuel Adebayor and Aaron Lennon, while Vlad Chiriches and Erik Lamela are likely to miss out.