More than 300 players will go through extensive medical examinations, interviews and workouts, while every coach, scout, general manager and even most owners watch with pitched intent.
The Detroit Lions will be well-represented among the NFL contingency. General manager Martin Mayhew and his personnel team will be looking for prospects for every round of the draft.
There will be a lot of candidates to choose from, as this draft appears quite deep with both athletic talent and football skill.
Here are some players who figure to be prime targets and late-round sleepers, as well as some players who are poised to put on quite a show at the Underwear Olympics.