Koeman's Feyenoord will be ready to punish any Vitesse failure.
Another exciting weekend of Eredivisie action kicks off on Friday night as PSV entertain Heracles; however, the pick of the action comes undoubtedly comes from De Grolsch Veste as Vitesse make the trip to FC Twente.
With 11 games remaining, the Eredivisie season is hitting crunch time, and for these two the stakes of Saturday's clash counter be higher. By full-time at least one of these clubs will effectively be ruled out of the title race.
In truth, even the winner will face an uphill battle if they want to dethrone Ajax—who lead FC Twente by four points, whilst Vitesse trail by a further point in fourth—but it's safe to say that whoever loses would need a miraculous turn around to lift the trophy in May.
For Michel Jansen's Twente, dropped points at Groningen in midweek mean that this is a game that they simply cannot lose. However, should they cut the champions' lead to just a solitary point, then the Amsterdam giants will feel the pressure heading into their equally difficult match against Heerenveen on Sunday. On the other hand, should Ajax win and FC Twente lose, then the 2010 winners are gone.
As for Vitesse, the Arnhem club is in dire need of a big result following a succession of poor performances since the winter break. Three points from a possible 12 has left Peter Bosz's side on the very edge, and if they cannot record a positive scoreline at De Grolsch Veste, then they too would see their dream ended.
The weekend's big winners could be third-placed Feyenoord, who travel to 10th-placed NAC Breda on Sunday. With the four teams directly around them all facing one another, points are going to be dropped so three points for Ronald Koeman's men would provide a big boost as they close in on a Champions League spot.
With only the top two qualifying for Europe's elite competition, sustaining good form is essential for every club involved.
At the other end of the table, the clash between Roda and Den Haag could be crucial in deciding which club is condemned to automatic relegation and which two will fight for survival in the dreaded play-offs.
Having stayed up via the end-of-season tournament last season, Jon Dahl Tomasson's Koempels will be particularly wary. The Danish legend took charge of Roda on Boxing Day; a win on Saturday would go a long way to securing their Eredivisie status next year.
The number of twists in recent weeks has ensured that this season heads toward a fascinating conclusion. You wouldn't want to predict the outcome of this weekend's action, but it should be another cracker. Game on!