Alberto Moreno finished off a strong buildup from Sevilla to give the hosts an early 1-0 lead over Barcelona in the 15th minute.
Ivan Rakitic cut in from the right before trading passes with Diogo Figueiras. Rakitic pulled back for Vitolo, who layed off for Moreno.
Moreno fired to the far post. His shot took a favourable deflection and past Victor Valdes.