The Los Angeles Lakers (18-32) defeated the Philadelphia 76ers (15-36) behind a season-high 19 points and five assists from Steve Nash on his 40th birthday.
The Sixers have now lost five games in a row and seven straight at home.
After torching the Lakers to the tune of 64 first-half points, the Sixers' offense stalled in the second half, managing a combined 34 points over the third and fourth quarters.
Conversely, the Lakers' offense hit its stride during the game's final 24 minutes and outscored the Sixers by 12 in the fourth quarter to cap off a second-straight win.
In total, six Lakers players finished in double figures, including Steve Blake, who totaled 14 points, eight assists and zero turnovers in a superb and gutsy effort.
Chris Kaman and Jordan Hill added 17 and 14 points, respectively, off the bench, and combined to pull down 14 rebounds.
Ryan Kelly added 15 points on 7-of-12 shooting and Wes Johnson tacked on 17 points and a game-high five steals in the win.
Tony Wroten led the Sixers with 16 points on 6-of-9 shooting off the bench while rookie Michael Carter-Williams was shaky, scoring 10 points on 4-of-12 shooting while dishing out seven assists and pulling down six rebounds.
Evan Turner was one of seven Sixers to finish in double figures (15 points, seven rebounds), but joined Carter-Williams as the team leader with four turnovers.
Next up for the Lakers is a showdown with the Chicago Bulls on Sunday while the Sixers will square off against the Los Angeles Clippers after a day off on Saturday.