The hosts find themselves in a fairly dire run of form, winning just two out of the last nine, although both were at home, whilst the visitors have an even worse record on their travels.
Blucerchiati have only won two of their last 19 away fixtures in the league and even if you consider that form generally goes out of the window for a derby match, the visitors still don't fare well having lost six of the last 10 meetings between the two sides.
There might not be too many fans around to see the game either.
Supporter groups from both teams have decided to boycott the fixture because of its early kick-off time, according to BBC Sport.
When: Sunday, February 2 at 6.30 a.m. ET
Sunday, February 2 at 11.30 a.m. GMT
Where: Stadio Luigi Ferraris, Genoa, Italy
The Grifoni have not won two games in succession since November but will be heartened by their performance in the 3-3 draw against Fiorentina last time out and a home win against Inter Milan the previous week.
Alberto Gilardino will lead the line again. He was on the scoresheet last week, and it will be interesting to see how a Sampdoria back four including Daniele Gastaldello and Shkodran Mustafi cope with the aerial bombardment.
Juraj Kucka remains absent after his cruciate injury towards the end of last year, and the hosts are further weakened by the loss of Alessandro Gamberini.
By contrast Sinisa Mihajlovic has the luxury of a full squad to choose from. His team were denied all three points against Bologna last time out, a stoppage time penalty a cruel way to have victory snatched away.
Mihajlovic hopes that lessons will be learned from the game. According to Football Italia he said: “We should’ve controlled the tempo better and this must serve as a lesson for us.”
An attacking 4-2-3-1 set up will take the game to Genoa, and the manager's only real decision involves who to play at left-back. Andrea Costa should take up his usual place, however the return of Vasco Regini from suspension gives Mihajlovic some food for thought.
Who will win the "Lighthouse Derby"
Sampdoria have only taken the points once at this venue since the late 1980s but will be desperate to avenge the 3-0 loss in the reverse fixture back in September.
The carrot for the visitors is that a win will bring them to within two points of their rivals and drag them further clear of the relegation places that they remain perilously close to at this point.
Three points for Genoa could see them ease into the top 10 and although their recent form has also been patchy at best, home advantage should be decisive in this one.
Genoa 2-1 Sampdoria