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Can four Ballon d'Or's ever be equalled?
If you take a moment to digest the many glittering highlights of Messi's career so far, this is actually a far more difficult question to answer than you think.
The player himself has often said that he does not care for individual awards, according to Spanish newspaper El Pais (via Inside Spanish Football), but four consecutive Ballon D'Or's cannot simply be ignored.
Scoring against every La Liga team consecutively is surely a record that will never be equalled and must go down as one of his best ever accomplishments.
An unbelievable return of 91 goals in a calendar year is also likely to stand the test of time.
Being a major part of Pep Guardiola's sextuple-winning side, a feat never before achieved in 150 years of football around the world.
Becoming Barcelona's all-time record scorer, and about to become leading El Clasico scorer, leading Champions League scorer and all-time highest scorer in La Liga.
None of these achievements are insignificant, and there are others.
Perhaps it won't even be anything to do with football.
After all, Messi plays an active part as a Unicef ambassador and is also figurehead for the Lionel Messi Foundation for which he said this:
One day, after a visit to a hospital, I realised the special dimension of a public figure. I understood that to these sick children the presence of a known player can be very helpful.
You are there and they smile, and for them it's a special joy because they are most eager to keep fighting, they really believe they will outgrow the disease and to pursue their dreams.
I reached my dream of becoming a footballer, and I want you to know that I fought hard to get there and I have to fight even harder to keep.
That effort and that success, I want to use it to help children who need it most, because that is what I chose. I get excited every day that a child smiles when he thinks that there is hope, when I see him happy.
So we decided to create the Foundation Leo Messi. And I will keep fighting to bring joy to children with the same force and intensity that I need to remain a footballer.
To choose just one single aspect from a hugely successful career would be almost impossible.