Chelsea kept alive their hopes of FA Cup glory thanks to a 1-0 win against Stoke City at Stamford Bridge.
But West London neighbours Fulham struggled to a 1-1 draw against Sheffield United and now face the prospect of a replay.
And there will be high-profile casualties in the FA Cup fifth round after Manchester City were drawn to play Chelsea, and Arsenal drawn against Liverpool.
Below is the complete fifth-round draw of the FA Cup:
|FA Cup Fifth-Round Draw|
|Home Team||Away Team|
|Sheffield United or Fulham||Nottingham Forest or Preston|
Top Teams To Face Off
The Premier League's top four sides were drawn to face one another in the fifth round of the FA Cup.
That means two of Manchester City, Chelsea, Arsenal and Liverpool join Manchester United and Tottenham in exiting the competition before the quarter-final stage and gives a side outside the traditionally big sides another chance to win some silverware, which can only be positive for the tournament's drama.
Telegraph journalist Henry Winter speculated about which games will be chosen for live TV coverage:
Elsewhere, Capital One Cup finalists Sunderland were rewarded for beating non-league Kidderminster by being drawn to face Southampton, and Everton manager Roberto Martinez faces a trip to his old club Swansea.
FA Cup holders Wigan will travel to the Premier League's bottom side, Cardiff, while Sheffield United, the lowest-ranked side left in the competition, will face Nottingham Forest or Preston if they can overcome Fulham.
Chelsea Won't Miss Mata
Juan Mata may be gone but Chelsea will not miss him if the form of Oscar against Stoke was anything to go by.
The Brazil international gave Chelsea a first-half lead in the FA Cup fourth-round tie at Stamford Bridge in an impressive all-round display.
His free-kick after 27 minutes left Stoke goalkeeper Asmir Begovic with little chance and increased his tally for the season to nine in all competitions.
It was Chelsea's 10th victory in 11 games, and they seem to be quietly hitting form at the right time, with Oscar central to all their good work.
The player's work ethic has improved immeasurably under Jose Mourinho, and his willingness to get behind the ball when Stoke held possession was also an asset to his team.
Blades Cut Cottagers Down To Size
Premier League strugglers Fulham took their poor league form into the FA Cup as they failed to beat 10-man Sheffield United at Bramall Lane.
Rene Meulensteen's side fell behind to a goal from Chris Porter in the 31st minute, but were handed a lifeline when Michael Doyle was sent off for the hosts. Hugo Rodallega eventually scored an equaliser for Fulham, and they will now have a second chance to take on the League One side.
Meulensteen rang the changes ahead of the game, naming a completely different side to the one that lost against Arsenal last weekend, and he paid the price for his rotation.
Former England defender Danny Mills told Chris Bevan of BBC Sport that United thoroughly deserved their replay:
Fulham had a few decent chances, but Sheffield United thoroughly deserved a replay. The sending off changed the game, as Fulham started to believe.
Sheffield United worked very hard, as it was tough conditions to play with 10 men. They defended strongly.
The FA Cup may not be Fulham's priority but it is symptomatic of a wider problem, and they must improve form and morale quickly if they are to beat relegation in the Premier League. A convincing cup run would boost confidence and improve form, so they should take it a bit more seriously.
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