With Manchester United and Tottenham already out of this year's FA Cup, the big sides have been served with a warning that they can't take their route to the later stages for granted.
Manchester City, seemingly unplayable at the moment, were held by Championship side Blackburn in the third round, Aston Villa were beaten by League One's Sheffield United and West Ham were thrashed by Nottingham Forest.
In the fourth round, the Premier League's top four, Arsenal, Man City, Chelsea and Liverpool, are all in action and it will be interesting to see how they approach the cup with important league games on the horizon.
Below is a full breakdown of every fourth round game as we approach another weekend of FA Cup action with potential for thrills, spills and upsets galore.
|FA Cup Fourth Round Fixtures and Predictions|
|Arsenal vs. Coventry||Jan 24||7:45 p.m. GMT||3-0||BT Sport|
|Nottingham Forest vs. Preston||Jan 24||8 p.m. GMT||2-1|
|Bournemouth vs. Liverpool||Jan 25||12:45 p.m. GMT||2-3||ITV|
|Birmingham vs. Swansea||Jan 25||3 p.m. GMT||1-3|
|Bolton vs. Cardiff||Jan 25||3 p.m. GMT||1-2|
|Huddersfield vs. Charlton||Jan 25||3 p.m. GMT||1-1|
|Manchester City vs. Watford||Jan 25||3 p.m. GMT||4-0|
|Port Vale vs. Brighton||Jan 25||3 p.m. GMT||0-2|
|Rochdale vs. Sheffield Wed||Jan 25||3 p.m. GMT||2-0|
|Southampton vs. Yeovil||Jan 25||3 p.m. GMT||3-0|
|Southend vs. Hull||Jan 25||3 p.m. GMT||2-2|
|Sunderland vs. Kidderminster||Jan 25||3 p.m. GMT||1-1|
|Wigan vs. Crystal Palace||Jan 25||3 p.m. GMT||1-3|
|Stevenage vs. Everton||Jan 25||5:30 p.m. GMT||0-3||BT Sport|
|Sheffield United vs. Fulham||Jan 26||1 p.m. GMT||1-3||BT Sport|
|Chelsea vs. Stoke||Jan 26||3:30 p.m. GMT||3-0||ITV|
Arsenal vs. Coventry
With the fixtures coming thick and fast for the Gunners, Arsene Wenger could take the opportunity to assess his squad's depth against League One Coventry on Friday evening.
As reported by Sky Sports, Wenger has claimed a signing in the January transfer window is unlikely. So it is down to those in the squad to help end the wait for silverware.
Per Arsenal's official website, Nicklas Bendtner is back in contention, while the likes of Alex Oxlade-Chamberlain and Lukas Podolski could also be given a chance, as could some of the club's younger players.
Coventry, unbeaten in 2014, will put up a fight but expect Arsenal to outclass them and win by a comfortable margin.
Prediction: Arsenal 3-0 Coventry
Bournemouth vs. Liverpool
Liverpool will also look to test their squad depth when they travel to the south coast on Saturday and although they will not start a full side against the Cherries, they are likely to keep plenty in reserve in order to avoid an upset similar to last season when they were dumped out of the FA Cup by Oldham.
Brendan Rodgers has built a strong first team at Liverpool, but they are struggling defensively and injury to Glen Johnson, confirmed by Rodgers on Thursday, and reported by Carl Markham in the Independent, leaves the club short of options.
The Reds should progress but as they tinker with formations and personnel, an organised and hardworking Bournemouth side could test their mettle.
Prediction: Bournemouth 2-3 Liverpool
Sunderland vs. Kidderminster
Sunderland's midweek exploits could take their toll, both physically and mentally, following a penalty shootout win against Manchester United in the Capital One Cup semi-final second leg that came after playing 120 minutes.
Although the Black Cats will be on cloud nine, and the players will be trying to earn a place in the team for the trip to Wembley, manager Gus Poyet is likely to make changes with one eye on the Premier League.
Ultimately top-flight survival is the most important thing on the club's agenda and it is within reach after a much-improved run of form in recent weeks. But if they take their eye off the ball they could be caught out, in classic FA Cup style, by a spirited Kidderminster side pushing for promotion from the Conference.
Prediction: Sunderland 1-1 Kidderminster