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Nottingham Forest vs. Preston (Friday, 8 p.m. GMT)
Shortly after Arsenal get going, high-flying Forest host Preston. Can the home side combine an encouraging season in the Championship with the added burden of a successful cup run?
Birmingham vs. Swansea City (Saturday, 3 p.m. GMT)
Another Championship vs. Premier League clash takes place in the West Midlands on Saturday afternoon. Birmingham, however, will fancy their chances more than most this weekend to shock their rivals and advance.
Bolton vs. Cardiff (Saturday, 3 p.m. GMT)
Cardiff have been in pitiful form throughout the Premier League season. However, Bolton have not set the Championship alight, either. The Welsh side could get a well-needed confidence boost in the Reebok Stadium.
Huddersfield vs. Charlton (Saturday, 3 p.m. GMT)
This all-Championship tie represents the best chance of making a mark on the 2013/14 season for both clubs. Huddersfield and Charlton will give their all on Saturday in the hope of making the fifth round.
Port Vale vs. Brighton (Saturday, 3 p.m. GMT)
Both Port Vale in League One and Brighton of the Championship are hopeful of promotion come May. On the verge of the play-offs, the pair can use an encouraging FA Cup run as a springboard to the top six.
Rochdale vs. Sheff Wed (Saturday, 3 p.m. GMT)
Rochdale are one of only two League Two sides left in the FA Cup as we enter the fourth round. Two divisions represents a big jump up in quality against the Owls, who nevertheless are in poor form and vulnerable.
Southampton vs. Yeovil (Saturday, 3 p.m. GMT)
The Saints are without former chairman Nicola Cortese, but still have Mauricio Pochettino at the helm after the Argentine opted to stay on. The manager will hope to keep on-pitch matters positive with a win at home to dangerous Yeovil.
Southend vs. Hull (Saturday, 3 p.m. GMT)
The second lowest-ranked team in the FA Cup welcome Premier League opposition to Essex.
Wigan vs. Crystal Palace (Saturday, 3 p.m. GMT)
Any hopes Wigan had for a quick return to the Premier League are fading fast. The chance to give higher-division opposition a bloody nose, in the shape of Crystal Palace, could help to restore some pride to the struggling Latics.
Stevenage vs. Everton (Saturday, 5.30 p.m. GMT)
Floundering at the foot of League One, Stevenage will have to play the game of a lifetime to get a result at home to the powerful Toffees.
Sheff United vs. Fulham (Sunday, 1 p.m GMT)
The Blades have a strong cup tradition, and will hope that and home advantage give them the edge against Premier League opposition.